FUNCTIONALLY OVERLAPPING INTRA- AND EXTRALYSOSOMAL PATHWAYS PROMOTE BIS(MONOACYLGLYCERO)PHOSPHATE SYNTHESIS IN MAMMALIAN CELLS

Functionally overlapping intra- and extralysosomal pathways promote bis(monoacylglycero)phosphate synthesis in mammalian cells

Abstract Bis(monoacylglycero)phosphate (BMP) is a major phospholipid constituent of intralumenal membranes in late endosomes/lysosomes, where it regulates the degradation and sorting of lipid cargo.Recent observations suggest that the Batten disease-associated protein CLN5 functions as lysosomal BMP synthase.Here, we show that transacylation reacti

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Efficient Mining of Non-Redundant Periodic Frequent Patterns

Periodic frequent patterns are frequent patterns which occur at periodic intervals in databases.They are useful in decision making where event occurrence intervals are vital.Traditional algorithms for discovering periodic frequent patterns, however, often report a large number of such patterns, most of which are often redundant Classic Body as thei

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